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KMID : 0043319960190020100
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Archives of Pharmacal Research
1996 Volume.19 No. 2 p.100 ~ p.105
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Measurement of ileal permeability with different-sized polyethylene glycols (PEG 400, 600 and 1000)
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Kim Mee-Hye
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Abstract
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Polyethylene glycols (PEGs; 400, 600, and 1000) were used to study the molecular weight (MW) permeability dependence in the rat ileal mucosa. Absorption of the PEGs was measured by following their recirculation perfusion over a 3 hr collection period. HPLC methods were used to separate and quantitate the individual oligomers present in the solution of PEGs mixtures (MW range 330 to 1 1 22 D). In the range studied, a distinct molecular weight cutoff was not identified. Corrected for the length of ileum used in the study, over the molecular weight range 330 to 1122 D, the apparent permeability of PEG ranged from Also, it was observed that the apparent permeability was inversely proportional to approximately $MW^{2.4}$.
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KEYWORD
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intestinal permeability, Polyehylene glycols, Small intestine
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